Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system
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منابع مشابه
Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.
beta-NAD(+) is as abundant as ATP in neuronal cells. beta-NAD(+) functions not only as a coenzyme but also as a substrate. beta-NAD(+)-utilizing enzymes are involved in signal transduction. We focus on ADP-ribosyl cyclase/CD38 which synthesizes cyclic ADP-ribose (cADPR), a universal Ca(2+) mobilizer from intracellular stores, from beta-NAD(+). cADPR acts through activation/modulation of ryanodi...
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Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate were discovered >2 decades ago. That they are second messengers for mobilizing Ca(2+) stores has since been firmly established. Separate stores and distinct Ca(2+) channels are targeted, with cyclic ADP-ribose acting on the ryanodine receptors in the endoplasmic reticulum, whereas nicotinic acid adenine dinucleotide phosphate m...
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The contractility of airway smooth muscle cells is dependent on dynamic changes in the concentration of intracellular calcium. Signaling molecules such as inositol 1,4,5-trisphosphate and cyclic ADP-ribose play pivotal roles in the control of intracellular calcium concentration. Alterations in the processes involved in the regulation of intracellular calcium concentration contribute to the path...
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Cyclic ADP-ribose (cADPR) is a naturally occurring metabolite of NAD+ that is as potent as inositol 1,4,5-trisphosphate (IP3) in mobilizing Ca2+ in sea urchin eggs. Previous pharmacological evidence suggests that cADPR acts through a system similar to the Ca(2+)-induced Ca2+ release (CICR). Here I showed that in the presence of low concentrations of cADPR addition of Ca2+ to egg homogenates sti...
متن کاملDesign and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Calcium Ion-Mobilizing Second Messenger**
because of their potential usefulness for investigating the mechanisms of cADPR-mediated Ca release and application as lead structures for the development of drug candidates. cADPR is very unstable and can be hydrolyzed not only by cADPR hydrolase in cells but also in neutral aqueous solution at the labile N1-ribosyl linkage. We previously synthesized cyclic ADP-carbocyclic-ribose (cADPcR, 2) a...
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ژورنال
عنوان ژورنال: Neurochemistry International
سال: 2007
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2007.06.023